ZFIN Image: Cheng et al., 2015, Fig. 3

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Figure Caption

Fig. 3

Knockdown of Her2 causes developmental abnormalities. (A) Embryos co-injected with 52her2-EGFP cRNA and control morpholino showed strong expression of EGFP (left panel). In contrast, the EGFP signal was abolished in embryos co-injected with 52her2-EGFP cRNA and her2 MO1 (right panel). (B) Representative images of morpholino-injected embryos. The asterisks denote edema in the fourth ventricle. Brain malformation is marked by arrows. These morphological phenotypes can be rescued by concomitant injection with 2 ng her2 cRNA. The bottom panels are the enlarged brain regions of the upper panels. Note that the structure of the midbrain-hindbrain boundary was unaffected by the her2 morpholino (arrowheads).

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Acknowledgments

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Reprinted from Developmental Biology, 397(1), Cheng, Y.C., Chiang, M.C., Shih, H.Y., Ma, T.L., Yeh, T.H., Huang, Y.C., Lin, C.Y., Lin, S.J., The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis, 116-28, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.