ZFIN ID: ZDB-IMAGE-150318-22
Expression analysis of podocyte specific transcripts nephrin and podocin show a range of failed migration and/or morphogenesis phenotypes in double prkCI/ζ morphant embryos. At 72 hpf, podocytes in wild-type controls (left panels) have migrated and fused at the midline to form a central glomerulus, that express (A) podocin and (B) nephrin (top row 4× magnification; bottom row 10× magnification). In double prkCI/ζ morphants, podocytes do not migrate normally to the midline, as shown by the pattern of (A) podocin and (B) nephrin expressing cells, and furthermore display variable migration patterns.
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