Fig. 1 Skolios mutants develop recessively inherited curvature of the body axis. A: Ventral curvature phenotypes observed in skolios mutant embryos at 3 dpf. B: Relative frequencies of ventral curvature phenotypes in WT and skolios embryos (3 dpf). C: Dorsal view of embryonic (4 dpf) and juvenile (17 dpf) zebrafish showing development of sagittal body curvature in skolios mutants. D: Severe body curvature in both the medial–lateral and dorsal–ventral planes of an adult skolios mutant. E: MicroCT imaging at approximately 50 dpf shows marked curvature of the abdominal (rib vertebrae) and caudal (vertebrae posterior to ribs) spine in skolios mutants.
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