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Maeda et al., 2014 - Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2

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Fig. S10 Decreased mechanosensitive responses of hair cells stably expressing Tmc2a^1–260-GFP-CAAX at 3 dpf. (A–A′′) Example of expression of the 260-aa N-terminal fragment in lateral-line hair cells. The bright oval-shaped puncta of exogenous Tmc2a fragments are enriched in apical hair bundles at the center of the rosette, although more label is present in the soma in comparison with the 117-aa fragment (Fig. S9). (Scale bar: 5 μm.) (B–D) Calcium transients in lateralline hair cells in response to 0.1-, 0.5-, and 1.0-s deflections. (E) Summary of responses normalized to transgenic R-GECO1 control hair cells.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA