ZFIN Image: Choe et al., 2014, Fig. 4

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Fig. 4

Synergistic pouch and cartilage defects in compound wnt11r; fgf8a mutants. (A-D) Alcama immunohistochemistry (green) labeled five pouches (p1-p5) in wild-type embryos at 34hpf. Compared with the mild reductions of pouches in wnt11r or fgf8a single mutants, compound wnt11r^-/-; fgf8a^-/- mutants had a near complete loss of pouches. Sensory ganglia are indicated with red asterisks. (E-H) Dissections of facial cartilage at 5dpf. Wild type had five CBs on each side, wnt11r and fgf8a single mutants had variable fusions and losses of on average one CB and compound wnt11r^-/-; fgf8a^-/- mutants lost multiple CBs. (I) Quantification of defects. Number of embryos examined (pouches, CBs): wild type (106, 102), wnt11r^-/- (66, 57), fgf8a^-/- (68, 98), and wnt11r^-/-; fgf8a^-/- (24, 20). Data represent mean±s.e.m. ***P<0.001 relative to fgf8a mutants alone. Scale bar: 40μm (A-D).

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Acknowledgments

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