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Fig. S1
Exogenous RA prevents the normal formation of secondary islets in larval fish. (A–B) Confocal z-stack projections of larval Tg(neuroD:GFP)nl1 pancreata dissected at 8 dpf. Larvae were treated with DMSO and different concentrations of RA from 5 to 8 dpf. 2° islet cells (green) in the tail region of pancreata are indicated by arrowheads. Pancreata are outlined in white dashed lines. Scale Bar, 100 μm. (C) Average number of 2° islet cells per 8 dpf larval pancreas. N=number of larval pancreata quantified. Error Bar represents standard error around the mean (SE). Significance, ***p<0.001.
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Reprinted from Developmental Biology, 394(1), Huang, W., Wang, G., Delaspre, F., Vitery, M.D., Beer, R.L., Parsons, M.J., Retinoic acid plays an evolutionarily conserved and biphasic role in pancreas development, 83-93, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.