ZFIN Image: Li et al., 2014, Fig. 11

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Fig. 11

Treatment with LiCl partly rescues cardiac defects caused by overexpression of miR-19b. Representative images of cardiac morphology (A, C, E, G and I) and cmlc2 in situ hybridization (B, D, F, H and J) are shown in 48 hpf zebrafish embryos. Mir-19b mimic-injected embryos displayed severe pericardial edema (G) and looping defects (H), which were rescued by treatment with 0.15 μm LiCl immediately after miR-19b injection (I and J). In contrast, cardiac morphology and looping were normal in WT (A and B), NC-injected (C and D) and 0.15 μm LiCl-treated embryos (E and F). Red arrow: ventricle; blue arrow: atrium; yellow arrow: pericardial edema.

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Acknowledgments

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