ZFIN Image: Schiavone et al., 2014, Fig. S8

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Figure Caption

Fig. S8

KRAS positive cells expressing Notch and TGFβ signaling reporters during MDB progression. Confocal zoom was performed on cerebellum tissue to observe the activity of TGFβ and Notch pathways at single-cell level. Normal (A and C) and Hyperplastic cerebella (B and D) are depicted, with scale bars for original (50 μm; A, B, C, D). The evidenced enlargement in panel B shows KRAS dependent activity of TGFβ pathway in MDB (tumor-prone green cells are also red reporter-positive). The enlargement in panel D shows KRAS dependent activity of Notch pathway in MDB (tumor-prone green cells are also red reporter-positive). Both pathways appear simultaneously involved in different ways during MDB onset and progression.

Acknowledgments

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