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Fig. 3

ID: ZDB-IMAGE-140902-115
Publication: Li et al., 2014 - Zebrafish Adar2 Edits the Q/R Site of AMPA Receptor Subunit gria2alpha Transcript to Ensure Normal Development of Nervous System and Cranial Neural Crest Cells
All Figures: Figures for Li et al., 2014

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Figure Caption

Fig. 3

Head morphology of hypo-Q/R-editing morphants.

(A) Bright-field images of morphants established in the wild type background between 24 to 72 hpf. The genotypes of the morphants are indicated on the top, where adar2MOc, adar2MOsp, adar2MOt, adar2MOt-p53^AUG and gria2αQRMO respectively indicate embryos receiving the mismatch morpholino (MOc), splicing blocker (MOsp), translation blocker (MOt), MOt plus p53-MO^AUG [22], and RNA editing blocker (QRMO) morpholinos. Developmental time is shown on the left. The brain ventricles are enlarged and the size of heads is reduced in the hypo-Q/R-editing morphants. (B) Bright-field images of p53 mutant (tp53^zdf1) receiving morpholinos described in (A) between 24 to 72 hpf. The morphological changes of adar2MO and gria2αQRMO cannot be suppressed by losing p53 activity.

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Phenotype details

Acknowledgments

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