ZFIN Image: Beretta et al., 2013, Fig. 4

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Fig. 4

Tcf7l2 function is required for ventral habenula (vHb) development. (a-c) Dorsal views, anterior to the top. kisspeptin-1 expression in the vHb (circle) is not affected by the upregulation of Wnt/beta-catenin signaling in (b)axin1 mutant embryos, but absent in (c)tcf7l2^exl/exl mutants. (a′-c′′′) MIPs, anterior to the left, dorsal views of axons innervating the MR in Et(1.0otpa:mmGFP)hd1 transgenic embryos. H2A-CFP labels the cell nuclei. (b′-b′′′) Upregulation of Wnt signaling in axin1 mutants does not affect MR innervation by vHb efferent axons. (c′-c′′′) In tcf7l2^exl/exl mutants, the MR are not innervated. White arrowheads and white boxes highlight the location of MR innervating axons, absent in (c′-c′′′). The gamma was adjusted to values between 0.70 and 0.80. vHb, ventral habenula; MR, median raphe.

Acknowledgments

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