ZFIN Image: Giustiniani et al., 2014, Fig. 5

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Figure Caption

Fig. 5 FKBP52 modulates pathological Tau activity in spinal primary motoneurons. (A–C) Lateral views of 48-hpf control embryos and FKBP52 morphant. Lateral views of znp1 antibody staining of control (D), FKBP52 morphant (E), Huc-Tau (F), and Huc-Tau injected with either FKBP52 MO (G) or FKBP52 mRNA (H) are shown at 48 hpf. (D2–H2) Tracings of motor-axon tracts ventral to the spinal cord derived from the panels directly above. In all images, anterior is to the left and dorsal is to the top. (Scale bars: A–C, 200 µm; D2–H2, 100 µm.) (I) Bar chart depicts the difference in the percentage of axons that reach their most ventral target. No significant difference is observed between WT and Huc-Tau + FKBP52MO embryos (N.S, P > 0.05; *P < 0.05; **P < 0.01). N.S, nonsignificant.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA