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Fig. S6
Dorsomorphin treatment enhances BMP ligand expression. In order to analyze regulation of BMP ligand expression, BMP signaling was inhibited with 100 μM dorsomorphin. To confirm BMP inhibition tbx5a expression was analyzed using in situ hybridization. Loss of tbx5a expression at 28 hpf indicates loss of BMP signaling (A-B). Expression of BMP ligands, gdf6a and bmp4 at 28 hpf, analyzed using in situ hybridization, is increased upon dorsomorphin treatment (C-F).
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Reprinted from Developmental Biology, 388(2), Holly, V.L., Widen, S.A., Famulski, J.K., and Waskiewicz, A.J., Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development, 192-204, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.