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Fig. 2 noi(pax2.1) expression is increased in aus mutant embryos. Dorsal (A,B) and lateral (C-F) views of whole embryos (A-D) or heads (E,F) with rostral to the left. (A-D) 6-somite-stage embryos. The expression domains of noi are expanded within the optic stalks and to a lesser extent at the mhb in the aus mutant embryo (B,D) compared to a wild-type sibling (A,C). (E,F) Prim-12 stage embryos. noi expression is upregulated within the optic stalk and mhb and ectopically expressed (arrowhead in F) within the telencephalon of the aus mutant embryo (F) as compared to a wildtype sibling (E). Abbreviations: d, diencephalon; mhb, midbrain/hindbrain boundary; os, optic stalk; ov, otic vesicle; p, pronephric duct; r, retina; wt, wild type. Scale bars: (A-D) 100 μm; (E,F) 50 μm.