ZFIN Image: Ono et al., 2014, Fig. 2

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Figure Caption

Fig. 2

Effect of FoxD overexpression on HNK-1 antigen and Sox10 expressions in chick neural tube. Upregulation of the HNK-1 epitope (middle column: B, E, H, K. N, Q, T, W) and Sox10 (right column: C, F, I, L, O, R, U, X) were induced by zebrafish FoxD3 (zFoxD3) and xFoxD3, but not by zFoxD1, xFoxD1, xFoxD2, mouse FoxD4, zFoxD5, or AmphiFoxD. Transfected cells were visualized by anti-GFP antibody in adjacent sections of embryos in which GFP-pCAGGS were co-electroporated (left column: A, D, G, J, M, P, S, V). Ectopic expression of the FoxD proteins was induced on the left-hand side of the neural tube. Numbers in the panel show the number of embryos in which marker overexpression was observed as a fraction of the number of embryos examined.

Acknowledgments

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Reprinted from Developmental Biology, 385(2), Ono, H., Kozmik, Z., Yu, J.K., and Wada, H., A novel N-terminal motif is responsible for the evolution of neural crest-specific gene-regulatory activity in vertebrate FoxD3, 396-404, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.