Fig. S6

Fig. S6

Cartoon Model of Dkk1b Production and Consequences During Zebrafish Fin Regeneration

(A) Regeneration in fins other than male pectoral fins. Dkk1b-producing cells are negligible in the regenerate at 2 dpa prior to regenerative outgrowth (left), but appear adjacent to less proliferative mesenchymal regions by 4 dpa (right). Because Dkk1b has inhibitory effects on blastemal proliferation and fin regeneration, its presence in one or both of these areas is likely to represent an inhibitory component of the regeneration niche. (B) Regeneration in male pectoral fins. Male pectoral fin ET constitutively produce Dkk1b, positioning this inhibitor in the site of regeneration at 2 dpa (left). By 4 dpa (right), interference by ET-generated Dkk1b inhibits blastema formation, directing initial growth ventrally and potentially mispatterning the regenerate.