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Fig. 1
Loss of Ptena and Ptenb leads to excessive filopodia formation in endothelial cells at 72 hpf. Endothelial cells in living wild-type (A) and ptena-/-ptenb-/- mutant (B) embryos were visualized using Tg(kdrl:eGFP) and confocal imaging was performed at 70–72 hpf. Intersegmental vessels along the trunk in ptena-/-ptenb-/- mutants (4/4) show excessive filopodia formation (arrowheads), whereas no filopodia were observed in wild-type (0/4) embryos. Anterior to the left, 40× + 1.5 zoom, 0.5 μm step size.
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Full text @ Dis. Model. Mech.