ZFIN Image: Kamel et al., 2013, Fig. 3

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Figure Caption

Fig. 3 Directed migration of CNCC proceed in frzb and fzd7a morphants but fail to undergo morphogenesis. Migration of the frontonasal CNCCs (A–D), maxillary CNCCs (E–H) and mandibular CNCCs (I–L). Anterior is to the left in all views. Photoconversion was performed unilaterally, with the contralateral side serving as internal control. CNCCs anterior to the eye at 14-somites stage (A) migrate to form the frontonasal process at 4.5 dpf (D), CNCCs medial to the eye at 14-somites (arrow, B) migrate to form the maxillary processes at 4.5 dpf (arrows, E), and CNCCs at 14-somites posterior to the eye (arrow, C) form the mandible at 4.5 dpf (arrow, F). In frzb and fzd7a morphants, CNCCs destined to form the frontonasal process migrated to the median portion of the dysmorphic and shortened palate (arrows, G, J). In frzb and fzd7a morphants, CNCCs destined to form the maxillary process converged in the midline (H, K), while CNCCs destined to form Meckel′s cartilage migrated to form the mandibular prominence but failed to converge in the midline (arrows, I, L).

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Acknowledgments

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Reprinted from Developmental Biology, 381(2), Kamel, G., Hoyos, T., Rochard, L., Dougherty, M., Tse, W., Shubinets, V., Grimaldi, M., and Liao, E.C., Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis, 423-33, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.