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Fig. 10
GRG5/AES represses Wnt signaling during early zebrafish embryogenesis.
Whole-mount in situ hybridizations for sp5l, a direct target of canonical Wnt signaling. Lateral view, dorsal to the right, of 70% epiboly stage-embryos. Injection of β-catenin induces broad ectopic domains of sp5l expression (B), which are reversed by co-injection of grg5/aes (C–E) or dntcf4 (F–H). Expression patterns in co-injected embryos were grouped in four classes, as above. AES reversed β-catenin-induced misexpression in 75% of the embryos (I). n: number of embryos tested.
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