ZFIN Image: Reimer et al., 2013, Fig. 6

Image

Figure Caption

Fig. 6 Early Disruption of Dopamine Signaling Has Long-Lasting Consequences for Motor Neuron Numbers and Swimming Behavior (A) Motor neuron numbers (lateral trunk views) are significantly reduced at 9 dpf by exposure to 10 μM L-745870 from 24 to 72 hpf (Kruskal-Wallis p = 0.0102 with Dunn’s multiple comparison, p < 0.05, p < 0.0001). Scale bar, 25 μm. (B and C) Incubation of embryos from 1 to 3 dpf decreases (B) the frequency of a startle response after touch at 4 dpf and (C) the total distance moved and high mobility frequency at 9 dpl (p < 0.01; p < 0.0001). Error bars represent SEM. See also Figure S5.

Figure Data

Expression / Labeling details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Cell, 25(5), Reimer, M.M., Norris, A., Ohnmacht, J., Patani, R., Zhong, Z., Dias, T.B., Kuscha, V., Scott, A.L., Chen, Y.C., Rozov, S., Frazer, S.L., Wyatt, C., Higashijima, S., Patton, E.E., Panula, P., Chandran, S., Becker, T., and Becker, C.G., Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration, 478-491, Copyright (2013) with permission from Elsevier. Full text @ Dev. Cell