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Fig. 7 Upregulation of BMP signaling in pnpla6 MO morphants. (A) Western blot of phosphorylated Smad1/5/8 levels at 24 hpf in four groups of embryos, as described for Fig. 3J. β-actin was used as a loading control. (B) Dorsomorphin (DM) treatment rescued the curly tail phenotype of pnpla6 MO morphant embryos. Scale bar: 200 μm. (C) The curly tail phenotype of pnpla6 MO was rescued by inhibition of the BMP signal pathway with 6 μmol/l DM; *P<0.001 compared with control MO group.
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Full text @ Dis. Model. Mech.