ZFIN Image: Veerkamp et al., 2013, Fig. S2

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Figure Caption

Fig. S2 L/R asymmetry of Bmp signaling within the heart requires Nodal activity. (A) Quantification of L/R asymmetry of nuclear dmKO2 intensity levels, which is significant in WT, but is abolished in spaw morphant embryos at 18 hpf (mean with s.d. based on quantifications of three hearts per genotype; p<0.05, *). (B) Dorsal view onto cardiac field in Tg[BREAAVmlp: dmKO2]^mw40 transgenic embryos, which indicates symmetrical Smad-1/5/8-mediated activities in spaw morphant hearts at 18 hpf. Signaling intensities are indicated by color range. Shown is one of three embryos analyzed per genotype. Mean intensity plots are a measure of the entire intensities within the field of view. Scale bar is 50μm. L, left; R, right; ns, not significant.

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Reprinted from Developmental Cell, 24(6), Veerkamp, J., Rudolph, F., Cseresnyes, Z., Priller, F., Otten, C., Renz, M., Schaefer, L., and Abdelilah-Seyfried, S., Unilateral dampening of bmp activity by nodal generates cardiac left-right asymmetry, 660-667, Copyright (2013) with permission from Elsevier. Full text @ Dev. Cell