ZFIN Image: Henriques et al., 2013, Fig. 6

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Figure Caption

Fig. 6 Elimination of tp53 function partially rescues tert^-/- degeneration in proliferative tissues.

tert^-/-tp53^-/- show increased proliferation and apoptosis in both testes (Ac, d and e, f) and gut (Bc, d and e, f), as compared to tert^-/- alone. In the testis, dashed outline represents spermatogenic zone, uniform outline proliferative zone of maturing spermatocytes and L the lumen where mature sperm is located. Elimination of tp53 function partially rescues mature sperm numbers (Aa, b) but completely rescues gut villi length (Ba, b). DNA damage as assessed by 53BP1 is maintained in tert^-/-tp53^-/- testes (Ag and h) and decreased in the gut (Bg and h), as compared to tert^-/-. N≥3. Data are represented as mean +/- SEM. Scale bar = 50 μm.

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