ZFIN Image: Cao et al., 2012, Fig. 7

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Figure Caption

Fig. 7

HMGB3 and HMGB3ΔC inhibit mesoderm gene expression and mesoderm formation in Xenopus whole embryo. Synthetic mRNA was injected along with the Lac Z mRNA as a cell lineage tracer at the 4-cell stage and in situ hybridization was performed using the markers as indicated on the top at the early gastrula (A-I), late gastrula (J-Q) or tail-bud (P-R) stage in control or injected embryos as indicated on the left. (A-C) Vegetal view of Xbra expression. (D-F) Dorso-vegetal view of type II cytokeratin expression. (G-I) Dorso-vegetal view of Xema expression. (J-L) Dorso-vegetal view of sox2 expression. (M-O) Dorsal view of sox3 expression. (P-R) Lateral view of myosin light chain (MLC) expression. Arrows indicate the dorsal lip of blastopore.

Acknowledgments

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Reprinted from Mechanisms of Development, 129(9-12), Cao, J.M., Li, S.Q., Zhang, H.W., and Shi, D.L., High mobility group B proteins regulate mesoderm formation and dorsoventral patterning during zebrafish and Xenopus early development, 263-274, Copyright (2012) with permission from Elsevier. Full text @ Mech. Dev.