ZFIN Image: Cao et al., 2012, Fig. 4

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Figure Caption

Fig. 4 HMGB3 differentially regulates dorsoventral mesoderm gene expression. (A1–B5) Animal pole view of chordin (A1-A5) and flh (B1-B5) expression at the shield stage in control and embryos injected with wild-type hmgb3 or its mutants, as indicated on the top. Dorsal region is to the right. The expression of these genes is expanded in hmgb3-, hmgb3ΔC- and hmgb3EnR-injected embryos. (C1-C5) Lateral view of sqt expression which is reduced in hmgb3-, hmgb3ΔC- and hmgb3EnR-injected embryos. (D1-I5) Animal pole view of fgf8 (D1-D5), wnt11 (E1-E5), wnt8a (F1-F5), tbx6 (G1-G5), vent1 (H1-H5) and vox (I1-I5) expression at 50% epiboly. For F1-I5, dorsal is to the right. Note that HMGB3, HMGB3ΔC and HMGB3EnR inhibit vox expression in the ventrolateral region of mesoderm, but expand its expression in the ectoderm.

Acknowledgments

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Reprinted from Mechanisms of Development, 129(9-12), Cao, J.M., Li, S.Q., Zhang, H.W., and Shi, D.L., High mobility group B proteins regulate mesoderm formation and dorsoventral patterning during zebrafish and Xenopus early development, 263-274, Copyright (2012) with permission from Elsevier. Full text @ Mech. Dev.