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Publication: Baxendale et al., 2012 - Identification of compounds with novel anti-convulsant properties in a zebrafish model of epileptic seizures
All Figures: Figures for Baxendale et al., 2012

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Fig. S1 Analysis of apoptosis in the CNS of drug-treated embryos using TUNEL. Anticonvulsant compounds were administered to 50 hpf embryos for 90 minutes in multi-well plates, at a final concentration of 10 μM. PTZ was administered at a final concentration of 20 mM and VPA was administered at a final concentration of 1 mM. Embryos were fixed and analysed for the presence of apoptotic cells using TUNEL. Each panels shows a dorsal view of the brain of an embryo exposed to the indicated compound. No significant induction of apoptosis was observed after treatment of embryos with any of the selected compounds.

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