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Fig. S7
(related to Figure 6). Retinoic acid restricts the number of Isl1+ cardiac progenitors
(A) Relative expression level of Isl1 and Nkx2.5 normalized to Rpl13α in pools of control embryos (n=10) and embryos, treated with 0.1 μM RA (n=10) or 0.3 μM RA (n=10) at 10 somites. Error bars represent standard deviations derived from two independent pools of control and RA treated embryos. (B) In situ hybridization for Isl1 in control and RA treated zebrafish embryos at 10 somites. (C) In situ hybridization for Isl1 in control and DEAB treated zebrafish embryos at 10 somites.
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Reprinted from Developmental Cell, 23(1), Witzel, H.R., Jungblut, B., Choe, C.P., Crump, J.G., Braun, T., and Dobreva, G., The LIM Protein Ajuba Restricts the Second Heart Field Progenitor Pool by Regulating Isl1 Activity, 58-70, Copyright (2012) with permission from Elsevier. Full text @ Dev. Cell