ZFIN Image: Zhou et al., 2012, Fig. 1

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Figure Caption

Fig. 1

5-Nitrofurans Promote Melanocytotoxicity in Zebrafish (A and B) Examples of zebrafish embryos treated at 2 dpf for 48 hr with DMSO as a control, plus 5 μM NFN1 and 5 μM NFN1.1 (A) or 50 μM nifurtimox (B). Black melanocytes (red arrows) and melanocyte detritus (blue arrows) are indicated. (C) Chemical structures of the four 5-nitrofurans (NFN1–4 [Maybridge compounds BTB05727, SEW00138, BTB13657, and BR00087]) identified in a chemical screen for modulators of melanocyte development. The 5-NO₂-furan functional group shared between the 5-nitrofurans, including nifurtimox, is indicated in red. The chemical structure of NFN1.1. is identical to that of NFN1 but lacks the 5-NO₂ functional group required for activity (blue). See also Figur S1 and Movie S1.

Acknowledgments

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