ZFIN Image: McCarroll et al., 2012, Fig. S10

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Figure Caption

Fig. S10 BIO regulates Pax2a levels and promotes otic cell commitment through the Wnt pathway. (A,B) Tg(hsp70:tcfΔC-EGFP) embryos in which transgene was not activated were treated at 11 hpf with either DMSO (A) or 2.5μM BIO (B). In embryos treated with BIO we saw supernumerary Pax2+ cells in the otic vesicle and increased Pax2a levels. (C,D) Tg(hsp70:tcfΔC-EGFP) embryos that were heat-shocked at 10 hpf, yielded the same phenotype in both DMSO- (C) and 2.5µM BIO- (D) treated embryos, indicating that BIO is modulating Pax2 levels and otic fate via canonical Wnt (n=5 embryos per condition). Scale bar: 50 μm.

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