ZFIN Image: Lu et al., 2012, Fig. 1

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Figure Caption

Fig. 1

Effects of X-13 on angiogenesis in TG (Fli-1:EGFP) zebrafish embryos. (A) Representative brightfield images of zebrafish larvae from 48 to 96 hpf. Treatment with X-13 for up to 96 h did not adversely affect the normal development of zebrafish larvae; (B) Representative fluorescence microscopy images; and (C) The bar chart shows quantitative data. X-13 (10, 50, 100 μM) dose-dependently induced angiogenesis in zebrafish embryos with EGFP expressing SIV. The angiogenic activity of X-13 at 50 μM and beyond was comparable to that of VEGF at 100 ng/mL. Data are expressed as the mean ± SD. Results were obtained from six independent experiments (* p < 0.05 vs. control vehicle group).

Acknowledgments

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