ZFIN Image: Stewart et al., 2012, Fig. S4

Image

Figure Caption

Fig. S4

Epidermal cells do not give rise to zns-5 expressing blastema-populating osteoblasts. (A–D) High magnification visualization of mCherry⁺ epidermis from a 2 dpa Class 1 mosaic Tg(dusp6:Cre-ERT2, EAB:EGFP-FlEx-mCherry) fins imaged for mCherry expression (A, red) and stained with zns-5 antibodies (B, green). Nuclei are stained with Hoechst (blue). White arrows indicate mCherry⁺ epidermis that is negative for the osteoblast marker zns-5. Zns-5 positive osteoblasts are marked with a yellow arrow. The dashed yellow line indicates the site of amputation and a white dashed line indicates the border between epidermis and blastema.

Acknowledgments

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Reprinted from Developmental Biology, 365(2), Stewart, S., and Stankunas, K., Limited dedifferentiation provides replacement tissue during zebrafish fin regeneration, 339-349, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.