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Fig. 6
Newly regenerated bone is formed by pre-existing osteoblasts. (A–D, A*–D*) Whole mount images of a Tg(dusp6:Cre-ERT2, EAB:EGFP-FlEx-mCherry) Class 3 mosaic caudal fin containing mCherry labeled osteoblasts before amputation (A, A*), 1 dpa (B, B*), 4 dpa (C, C*), and 14 dpa (D, D*). The dashed box denotes the region magnified in the panel directly below. All cells are EGFP+ (green), except mCherry+ genetically recombined cells and their descendants (magenta). White arrows mark osteoblasts and yellow arrows denote cells co-labeled with mCherry+ osteoblasts.
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Reprinted from Developmental Biology, 365(2), Stewart, S., and Stankunas, K., Limited dedifferentiation provides replacement tissue during zebrafish fin regeneration, 339-349, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.