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Fig. S5 Abnormal Sonic Hedgehog signaling in arl6ip1-MO1/p53-MO morphants. (A-D) Lateral views of 24hpf embryos, anterior to the left. (A, B) Expression of shh was normal, either in wild-type embryos (A) or arl6ip1-MO1/p53-MO-injected embryos (B). (C, D) pax6, a gene negatively regulated by Shh signaling, was up-regulated in the neural tube of arl6ip1-MO1/p53-MO-injected embryos (D). Neural tube: indicated by arrow.
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