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Fig. 4
Xenopus zic3 rescues axial defects in zebrafish Zic3 morphants. (A–D) Live embryos at 5 days post-fertilization. (A) Uninjected control embryos. (B) Xzic3 mRNA-injected embryos showed subtle phenotypes including a curled tail tip. (C) Zic3 morphant embryos had a shortened and curved A–P axis and edema. (D) Embryos co-injected with Zic3 morpholino and Xzic3 mRNA. (E) Percentage of embryos with a curved or shortened axis. Embryos with minor curled tail tips were scored to have normal body elongation.
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Reprinted from Developmental Biology, 364(1), Cast, A.E., Gao, C., Amack, J.D., and Ware, S.M., An essential and highly conserved role for Zic3 in left-right patterning, gastrulation and convergent extension morphogenesis, 22-31, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.