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Fig. S5
HB-EGFa and Ascl1a are necessary for injury-dependent induction of Notch signaling component genes. Related to Figure 4. (A) In situ hybridization shows MO-mediated HB-EGFa knockdown suppresses injury-dependent induction of notch1 and her4 mRNAs. (B) RT-PCR shows MO-mediated Ascl1a knockdown suppresses injury-dependent induction of deltaB, C and D. (C) In situ hybridization shows Ascl1a knockdown suppresses injury-dependent induction of deltaA, notch1 and her4 mRNAs. Scale bar, 50 μm.
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Reprinted from Developmental Cell, 22(2), Wan, J., Ramachandran, R., and Goldman, D., HB-EGF Is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration, 334-347, Copyright (2012) with permission from Elsevier. Full text @ Dev. Cell