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Fig. S3
Injury-dependent induction of ascl1a mRNA expression requires HB-EGFa expression and EGFR activation. Related to Figure 3. Adult retinas were injured (* marks the injury site) and the effects of EGFR inhibition with PD153035 or MO-mediated HB-EGFa knockdown on ascl1a mRNA expression was examined using in situ hybridization assays. Scale bar, 50 μm.
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Reprinted from Developmental Cell, 22(2), Wan, J., Ramachandran, R., and Goldman, D., HB-EGF Is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration, 334-347, Copyright (2012) with permission from Elsevier. Full text @ Dev. Cell