ZFIN Image: Leacock et al., 2012, Fig. 1

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Figure Caption

Fig. 1

EWS-FLI1 induces SRBCTs in zebrafish. (A) Schematic of Tol2 transposons including the hsp70 or the β-actin promoter, FLAG-tag (black rectangle), human EWS-FLI1 coding sequence, IRES-GFP sequence (gray rectangle), flanked by Tol2 recombination sites (triangles). (B-H) H&E staining of sagittal sections of adult zebrafish. (B) Control adult zebrafish. Wild-type zebrafish injected with EWS-FLI1 developed an invasive leukemia like-tumor (C magnified in D) or a solid small round blue cell tumor of the eye (arrow in E) (E magnified in F). tp53 mutants injected with EWS-FLI1 transposons also develop leukemia (G) or solid tumors (H) with similar histology. Scale bars: 200 μm (B,C,E), 50 μm (D,F–H).

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