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ZDB-IMAGE-111207-2

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Ab1-en

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Jurynec et al., 2008 - Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle

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Fig. 2

Slow muscle fiber formation is reduced in sepN morphants. (A–F) Somitic muscle in midtrunk region of 24-hpf WT and sepN morphant embryos. (A and B) S58⁺ slow muscle fibers and (C and D) 4D9⁺ slow muscle pioneer fiber nuclei are present in reduced numbers in sepN morphants. Staining for dystrophin expression (E and F) reveals “u-shaped” somites in sepN morphant embryos. (G–J) Expression of myogenic lineage genes in adaxial cells of three-somite stage embryos. myoD (G and H) and α-cardiac actin (aca; I and J) are expressed discontinuously and at reduced levels in the adaxial cell population of sepN morphants. (A–F) Lateral views, rostral left. (G–J) Dorsal views, rostral left.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA