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Fig. 8
Apo-E-GFP positive microglia cells proliferate in the parenchyma in response to wounding. A: Overview of a telencephalic cross-section through the lesioned region stained with Draq5. White box marks the ventral part of the lesion. B: Quantification of microglia cells labeled with Apo-E-GFP or together with PCNA. A subset of Apo-E-GFP microglia is proliferation-competent at 3 dpl. C,D: High magnification of the boxed region in A. Overlay of Apo-E-GFP, PCNA and Draq5 (C). Colocalization of PCNA and Apo-E-GFP shows that microglia proliferate near the lesion (arrows C). Scale bar = 100 μm in A; 7.5 μm in B–E.
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