Image
|
Figure Caption
Fig. S5
Figure S5. Rac2 D57N partially inhibited CXCR4-WHIM induced neutrophil clustering, related to Figure 6.
(A) Sudan black staining of neutrophil clusters at the ventral side of the head where SDF-1 is expressed in Tg(mpx:CXCR4-WHIM). Rac2 D57N expression in neutrophil partially inhibits this clustering.
(B) Confocal images of neutrophil distribution at the ventral side of the head in Tg(mpx:CXCR4-WHIM, mpx:mCherry-2A-Rac2 WT or D57N) at 3dpf. Green, CXCR4-GFP; red, Rac2-2A-mCherry. Scale bar, 30 μm.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Reprinted from Developmental Cell, 21(4), Deng, Q., Yoo, S.K., Cavnar, P.J., Green, J.M., and Huttenlocher, A., Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue, 735-745, Copyright (2011) with permission from Elsevier. Full text @ Dev. Cell