ZFIN Image: Sorrell et al., 2011, Fig. 6

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Figure Caption

Fig. 6

Increasing Fgf signaling results in ectopic expansion of hand2 expression. (A–D) Expression of hand2 in heat-shocked control sibling and Tg(hsp70:ca-fgfr1)^pd3 embryos at 8s. (A) hand2 is expressed in anterior (cardiac) and posterior domains of the LPM, but absent in between these domains (arrow). (B) In a Tg(hsp70:ca-fgfr1)^pd3 embryo with increased Fgf signaling at the TB stage, expression of hand2 is expanded into this intermediate region of the LPM (arrow). (C,D) The anterior limit of hand2 expression (arrows) is the same in heat-shocked control sibling and Tg(hsp70:ca-fgfr1)^pd3 embryos with increased Fgf signaling at the TB stage. Asterisks in C and D indicate the anterior of the head. (A,B) Dorsal views of the trunk region. (C,D) Dorsal views of the anterior. In all images anterior is up.

Acknowledgments

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Reprinted from Developmental Biology, 358(1), Sorrell, M.R., and Waxman, J.S., Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation, 44-55, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.