ZFIN Image: Gregory-Evans et al., 2011, Fig. 1

Image

Figure Caption

Fig. 1

Effect of drug treatment on wildtype zebrafish. A: Wildtype embryos were dosed continuously from 10 hpf with diferuloylmethane. Percentage survival of embryos at 6 dpf was determined for each treatment group (30 embryos/group), n=3, mean±SEM. Error bars smaller than the symbol are not visible. B-E: Left panels, wholemount eye; center panels, coronal retinal section; right panels, wholemount larvae. B: Wildtype phenotype untreated at 6 dpf. C: Wildtype phenotype at 6 dpf treated with 5 μM diferuloylmethane from 10 hpf. D: Wildtype phenotype at 6 dpf following 300 μM zVAD-fmk treatment. E: Wildtype phenotype at 6 dpf following 300 μM zFA-fmk treatment. Scale bar left panel=200 μm. GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; RPE, retinal pigment epithelium, ON, optic nerve.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.