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Fig. S4
Apoptosis in esco2 morphants is independent of p53. A–H, BrdU-labeled proliferating cells at 24 hpf (A–D) and 48 hpf (E–H). Proliferation was normal in esco2 morphants (B, F, compare to wild type in A, E). Additional depletion of p53 in the p53M214K mutant line (p53 -/-, C, G) led to increased proliferation at 48 hpf (H), but not 24 hpf (D). I–N, TUNEL staining of apoptotic cells at 24 hpf (I, J) and 48 hpf (K–N). Apoptosis was severely increased in esco2 morphants (J, L, compared to wild type in I, K), and independent of additional depletion of p53 (M, N).
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