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Fig. S1
Wnt/β-catenin signaling is essential for liver formation. (A-D) The Tg(fabp10:dsRed,ela3l:EGFP) line was used to reveal hepatocytes (red) and acinar pancreatic cells (green). The liver formed in most Tg(hs:dkk1) embryos that were heat-shocked at 18 hpf (B; n=21 out of 24) and in most wnt2bb mutants (C; n=460 out of 506), although liver size was smaller than wild type. However, the liver did not form in most Tg(hs:dkk1);wnt2bb-/- embryos heat-shocked at 18 hpf (D; 86%, n=50 out of 58). Arrows indicate the liver; brackets mark the extent of the pancreas. Dorsal views, anterior upwards. Scale bar: 100 μm.
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