ZFIN Image: Klein et al., 2011, Fig. 6

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Figure Caption

Fig. 6 The postulated model. Left: Wnt2bb initiates migratory competence in endodermal cells by controlling Nav3a synthesis in the predetermined intestinal endoderm. Middle: In a second step, FGF and BMP alone or in combination with other ‘outgrowth factors’ might mediate translocation of Nav3a protein from Golgi apparatus to lamellipodia and filipodia in hepatoblasts. There, Nav3a interacts with Arp2/3-Abi1-dependent actin assembly complexes. Subsequently, Nav3a positively modulates actin assembly and thereby enables migrating hepatoblasts to follow their trajectory. Right: Nav3a expression is downregulated after completion of the liver bud. lb, liver bud; pb, pancreatic bud.

Acknowledgments

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