ZFIN Image: Fujita et al., 2011, Fig. S6

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Figure Caption

Fig. S6

Defects in lateral dorsal aorta formation in cxcl12b and cxcr4a morphants. Lateral dorsal aorta formation is incomplete in cxcl12b and cxcr4a morphants, with gaps between the rostral and caudal portions of these vessels in the head. (A-D) Confocal images of the head vasculature in 24 hpf Tg(fli1a:EGFP)^y1 animals injected with control MO (A), 2 ng cxcl12b-MO2 (B), 3 ng cxcr4a-MO2 (C), or 1 ng cxcl12b-MO2 + 1.5 ng cxcr4a-MO2 (D). Dorsal-lateral view. For ease of visualization, the anterior LDA is pseudocolored red, the posterior LDA is pseudocolored green, and veins are pseudocolored blue. Asterisks indicate abnormal gaps in LDA. (E) Quantification of the number of MO-injected embryos with no gaps (′present both′) or with gaps in the right (′absent right′), left (′absent left′), or both LDAs (′absent′) at 24 hpf. MO dosage is indicated (ng). Scale bar: 50 μm.

Acknowledgments

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