ZFIN Image: Bussmann et al., 2011, Fig. 5

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Figure Caption

Fig. 5

Time-lapse imaging of hindbrain vascular development in wt, cxcl12b^mu100 and cxcr4a^um21 mutant embryos. (A-C) Still images at 34, 38 and 42 hpf from confocal time-lapse movies of hindbrain vascular development in live wt (A), cxcl12b^mu100 (B) and cxcr4a^um21 (C) mutant kdrl:mem-rfp transgenic embryos (see Movies 7-9 in the supplementary material). Dorsal views, anterior to the left. (D) Transverse sections based on 3D reconstruction of the movies illustrated in A-C, highlighting the absence of ventral migration of CtA sprouts in cxcl12b^mu100 and cxcr4a^um21 mutant embryos (arrows). The schematic interpretations are based on 42 hpf still images as in Fig. 1I.

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Acknowledgments

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