ZFIN Image: Chun et al., 2011, Fig. 4

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Figure Caption

Fig. 4

Shh-VEGF-Notch-Hey2 signaling pathway regulates FEVPs proliferation at the LPM.

Etsrp WISH was performed on Tg(hsp70:gal4;uas:NICD) and Tg(uas:NICD) embryos. A-H shows etsrp⁺ cells of Tg(hsp70:gal4;uas:NICD) and Tg(uas:NICD) embryos in head, dorsal, trunk, and lateral. Temporal expression of NICD at 1 som resulted in induction of etsrp⁺ cells at 10 som. I to L show dorsal view of etsrp⁺ cells in uninjected (I), shh (J), vegf₁₆₅ (K) and vegf₁₂₁ (L) mRNA-injected embryos in trunk at 10 som. I2-L2 show lateral view of the 10 som etsrp WISH embryos. Vegf₁₆₅ mRNA (K) injected embryo shows more etsrp⁺ cells in outer line (yellow asterisk) and vegf₁₂₁ mRNA (L) injected embryos in inner line (asterisk). (See Figure S2 and S3). The numbers on the top right panel of all ISH embryos in this figure indicate number of embryos out of total number displaying that particular phenotype.

Acknowledgments

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