ZFIN Image: Tittle et al., 2011, Fig. S3

Image

Figure Caption

Fig. S3 The dnmt1^s904 allele phenocopies lens defects in uhrf1 mutants. (A) Wild-type and (B) dnmt1^s904 mutant embryos at 5 dpf. As in lenses of uhrf1 and dnmt1^s872 mutant embryos, dnmt1^s904 mutants display obvious lens defects and in the more severely affected embryos lens dysplasias are observed (arrow in B inset). (C,D) Transverse histology from (C) wild-type and (D) dnmt1^s904 mutant embryos at 5 dpf. The mild mutant lens phenotype shown in panel D demonstrates the range of lens defects observed in dnmt1^s904 mutants, which is consistent with the range observed in uhrf1 and dnmt1^s872 mutants. Scale bars are 80 μm.

Figure Data

Phenotype details

Acknowledgments

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Reprinted from Developmental Biology, 350(1), Tittle, R.K., Sze, R., Ng, A., Nuckels, R.J., Swartz, M.E., Anderson, R.M., Bosch, J., Stainier, D.Y., Eberhart, J.K., and Gross, J.M., Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens, 50-63, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.