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Fig. 1 Loss of Ngn1 function leads to loss of deltaA and deltaD expression.
Whole-mount in situ hybridization against ngn1 (A), deltaD (B, C) or deltaA (D, E) in zebrafish embryos at 11 hpf. Expression in wild type embryos show that ngn1, deltaD and deltaA share similar expression patterns (A, B, D). In ngn1 mutant embryos (C, E), deltaD and deltaA expression is strongly reduced in the anterior neural plate; this is most notable for the trigeminal ganglia (black arrows in B–E) and the medial clusters in rhombomeres 2 and 4 (white arrowheads in B–E). Embryos are viewed dorsally with anterior up.
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Reprinted from Developmental Biology, 350(1), Madelaine, R., and Blader, P., A cluster of non-redundant Ngn1 binding sites is required for regulation of deltaA expression in zebrafish, 198-207, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.