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Fig. 2 N-acetylcysteine prevents liver toxicity. (A) Survival was assessed in adult zebrafish exposed to 5 (blue), 10 (green), or 25 (red) mM APAP alone (solid line) and with 10 μM NAC (dashed line; n e 10 per group). (B) APAP-induced elevation of ALT is reversed by the addition of NAC. *ANOVA, P < 0.05, 15?20 fish for three replicates). (C) Zebrafish were exposed to APAP and NAC at the indicated doses; NAC decreased the extent of necrosis after APAP.
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Full text @ Proc. Natl. Acad. Sci. USA